Scientists identify genetic mechanisms involved in abnormal early brain development in young autism patients

Scientists identify genetic mechanisms involved in abnormal early brain development in young autism patients
Published: 23 March 2012 (805 Views)
US scientists have identified in young autism patients genetic mechanisms involved in abnormal early brain development and overgrowth that occurs in the disorder, according to a study published Thursday in the online journal of PLoS Genetics.

The study uncovered differences in gene expression between brain tissue from young (two to 14 years old) and adult individuals with autism syndrome disorder, providing important clues why brain growth and development is abnormal in this disorder.

The findings suggest novel genetic and molecular targets that could lead to discoveries of new prevention strategies and treatment for the disorder.

In the study, the researchers showed that genetic mechanisms that normally regulate the number of cortical neurons in young autism patients are abnormal.

In addition, they discovered a turning down of the genetic mechanisms responsible for detecting DNA defects and correcting or removing affected cells during periods of rapid prenatal development.

Autism is a highly heritable neurodevelopmental disorder, yet the genetic underpinnings in the brain at young ages have remained largely unknown.

Until now, few studies have been able to investigate whole-genome gene expression and genotype variation in the brains of young patients with autism, especially in regions such as the prefrontal cortex that display the greatest growth abnormality. 

- Xinhua

Tags: Brain, autism,
 0

You May Like These Videos

Comments

There are no comments.

Latest stories

'Mudzingwa, Munawa not spent forces'

by Staff reporter | 21 January 2018 | 82 Views

'Bond notes removal will stabilise prices'

by Staff reporter | 21 January 2018 | 182 Views

Ex-cop jailed for impersonation

by Staff reporter | 21 January 2018 | 111 Views

Female fraudster poses as Zimra official

by Staff reporter | 21 January 2018 | 112 Views

Mohadi speaks reconciliation

by Staff reporter | 21 January 2018 | 94 Views

Bulawayo residents threaten to sue town clerk

by Staff reporter | 21 January 2018 | 73 Views

Bosso Electoral Committee begins verification of nominees

by Staff reporter | 21 January 2018 | 56 Views

Mnangagwa fails to 'coup' cash crisis

by staff reporter | 21 January 2018 | 71 Views

Mnangagwa plans economic revival

by Bloomberg | 21 January 2018 | 63 Views

'Postponement of polls out of the question'

by Staff reporter | 21 January 2018 | 44 Views

Mnangagwa embarks on a charm offensive

by Staff reporter | 21 January 2018 | 81 Views

Who should be afraid of elections MDC-T or Zanu-PF?

by Bishop | 21 January 2018 | 85 Views

Majaivana unlikely to visit Zimbabwe anytime soon

by Staff reporter | 21 January 2018 | 67 Views

'Fake prophecies' haunts Makandiwa

by Staff reporter | 21 January 2018 | 106 Views

Mnangagwa takes Zimbabwe economic gospel to Davos

by Staff reporter | 21 January 2018 | 63 Views

Mnangagwa runs the rule on Cabinet

by Staff reporter | 21 January 2018 | 70 Views

Grace Mugabe's fancy vehicles in freak accident?

by Staff reporter | 21 January 2018 | 111 Views

MPs to get cars for free

by Staff reporter | 21 January 2018 | 68 Views

Tsvangirai captured?

by Staff reporter | 21 January 2018 | 88 Views

Thomas Mapfumo heads to Zimbabwe

by Staff reporter | 21 January 2018 | 80 Views

Vendors prepared to fight the soldiers

by Staff reporter | 21 January 2018 | 110 Views

Mnangagwa, Chiwenga rift exposed

by Staff reporter | 21 January 2018 | 172 Views

Mnangagwa takes Zim pitch to the world

by Staff Reporter | 21 January 2018 | 65 Views

Is Jah Prayzah strangling his own baby?

by Staff Reporter | 21 January 2018 | 121 Views

SA construction firm eyes Matabeleland venture

by Staff Reporter | 21 January 2018 | 53 Views

Mnangagwa sticks to his word, urges diaspora to register to vote

by Staff Reporter | 21 January 2018 | 83 Views

Sex worker on the run after stabbing a client

by Simbarashe Sithole | 21 January 2018 | 86 Views

Zanu PF strongholds have already rigged elections - analyst

by Stephen Jakes | 21 January 2018 | 49 Views

G40 will rally for Mujuru during elections - philosopher

by Stephen Jakes | 21 January 2018 | 84 Views

Setting the record straight on the political future of Mthwakazi

by staff Reporter | 21 January 2018 | 46 Views

ZimRights scales up BVR mobilisation

by Stephen Jakes | 21 January 2018 | 41 Views

Mnangagwa's final letter to Mugabe

by Staff Reporter | 21 January 2018 | 96 Views

Chiyangwa's fight for life

by Stephen Jakes | 21 January 2018 | 122 Views

Mnangagwa faces internal revolt over polls

by Staff Reporter | 21 January 2018 | 68 Views

Vendors give govt 48-hour ultimatum to create jobs

by Staff Reporter | 21 January 2018 | 79 Views